M'zaka za m'ma 1990, akatswiri azachipatala a ku Switzerland adapeza kuti mapulateleti amatha kutulutsa zinthu zambiri za kukula pamagulu akuluakulu, omwe amatha kukonza mwamsanga komanso moyenera mabala a minofu.Pambuyo pake, PRP idagwiritsidwa ntchito m'maopaleshoni osiyanasiyana amkati ndi kunja, opaleshoni yapulasitiki, kupatsirana khungu, ndi zina zambiri.
Tidayambitsa kale kugwiritsa ntchito PRP (Platelets Rich Plasma) pakuyika tsitsi kuti zithandizire kuchira kwa bala ndi kukula kwa tsitsi;Zoonadi, kuyesa kotsatira kuyesa ndikuwonjezera kuphimba tsitsi loyambirira mwa kubaya PRP.Tiyeni tiwone zomwe zidzachitike pobaya plasma yopangidwa ndi autologous platelet komanso zinthu zosiyanasiyana zakukulira mwa odwala aamuna omwe ali ndi alopecia, omwenso ndi mankhwala omwe tingayembekezere kugwiritsa ntchito kuthana ndi kutayika kwa tsitsi.
Asanayambe komanso panthawi yonse yopangira tsitsi, odwala omwe amathandizidwa ndi PRP ndi omwe sanabadwe ndi PRP amatha kupangitsa tsitsi kukula mofulumira.Nthawi yomweyo, wolemba adaperekanso kafukufuku wotsimikizira ngati plasma wolemera wa mapulateleti ali ndi zotsatira zofanana pakuwongolera tsitsi labwino.Ndi mtundu wanji wa chilonda chomwe chiyenera kugwiritsidwa ntchito komanso kuchuluka kwa kukula komwe kuyenera kubayidwa mwachindunji kuti ikhale yogwira mtima?Kodi PRP ingasinthe kuonda kwapang'onopang'ono kwa tsitsi mu androgenic alopecia, kapena ingalimbikitse kukula kwa tsitsi kuti kuwongolera androgenic alopecia kapena matenda ena otaya tsitsi?
M'miyezi isanu ndi itatu yoyesera yaying'ono, PRP idabayidwa pakhungu la androgenic alopecia ndi alopecia.Poyerekeza ndi gulu lolamulira, lingathedi kutembenuza tsitsi pang'onopang'ono;Kuonjezera apo, pamene jekeseni mwa odwala omwe ali ndi dazi lozungulira, tsitsi latsopano limatha kuwoneka patatha mwezi umodzi, ndipo zotsatira zake zimatha kupitirira miyezi isanu ndi itatu.
Mawu Oyamba
Mu 2004, pamene mmodzi wa ochita kafukufuku anachitira chilonda cha kavalo ndi PRP, chilondacho chinachiritsidwa mkati mwa mwezi umodzi ndipo tsitsi linakula, ndiyeno PRP inagwiritsidwa ntchito pa opaleshoni yopangira tsitsi;Ofufuzawo anayesanso jekeseni wa PRP pamutu wa odwala ena asanatengere tsitsi, ndipo adapeza kuti tsitsi la odwalawo likuwoneka kuti likukulirakulira (1).Ofufuzawo amakhulupirira kuti revascularization ndi zotsatira za kuchuluka kwa zinthu zomwe zikukulirakulira zimatha kulimbikitsa kukula kwa ma cell follicle atsitsi pamutu wamalo osagwira ntchito.Magazi amakonzedwa mwapadera.Mapulateleti amasiyanitsidwa ndi mapuloteni ena a plasma ndipo amakhala ndi mapulateleti ambiri.Kufikira muyezo wa achire zotsatira, kuchokera 1 microliter (0.000001 lita) munali 150000-450000 kupatsidwa zinthu za m`mwazi 1 microliter (0.000001 lita) munali 1000000 kupatsidwa zinthu za m`mwazi (2).
Platelet α ili ndi mitundu isanu ndi iwiri ya zinthu zomwe zimakula mu granules, kuphatikiza epithelial growth factor, fibroblast growth factor, thrombogen growth factor and transforming growth factor β, transforming growth factor α, Interleukin-1, and vascular endothelial growth factor (VEGF).Kuphatikiza apo, peptides antimicrobial, catecholamines, serotonin, Osteonectin, von Willebrand factor, proaccelenn ndi zinthu zina zimawonjezeredwa.Tinthu tating'onoting'ono tili ndi mitundu yopitilira 100 ya zinthu zomwe zimakula, zomwe zimatha kugwira zilonda.Kuphatikiza pa kukula kwa zinthu, mapulateleti a sparse plasma (PPP) ali ndi ma cell atatu adhesion adhesion molecule (CAM), Fibrin, fibronectin, ndi vitronectin, mapuloteni ambiri omwe amakhazikitsa dongosolo lalikulu ndi nthambi zowongolera kukula kwa maselo, kumamatira, kufalikira, kusiyana ndi kubadwanso.
Takakura, et al.adanena kuti chizindikiro cha PDCF (platelet derived growth factor) chikugwirizana ndi kugwirizana kwa ma epidermal hair follicles ndi dermal stromal cell, ndipo ndizofunikira pakupanga ma ducts atsitsi (3).Mu 2001, Yano et al.adanenanso kuti VFLGF imayang'anira kakulidwe ka tsitsi, ndikupereka umboni wachindunji kuti kukulitsa kukonzanso kwa mitsempha ya tsitsi kumatha kulimbikitsa kukula kwa tsitsi ndikuwonjezera kukula kwa tsitsi ndi kukula kwa tsitsi (4).
PS: Platelet derived growth factor, PDCF.Chinthu choyamba cha kukula chovomerezedwa ndi US FDA kuchiza kuvulala kwapakhungu kosatha ndi chinthu choyamba chakukula chomwe chimatulutsidwa ndi kukondoweza pambuyo povulala pakhungu.
PS: Vascular endothelial kukula factor, VEGF.Ndi imodzi mwazinthu zofunika kwambiri zowongolera zomwe zimayendetsa kuchuluka kwa ma cell endothelial, angiogenesis, vasculogenesis ndi mtima permeability.
Ngati timakhulupirira kuti pamene timitsempha tatsitsi taphwa moti sitingathe kuona kukula kwa tsitsi ndi diso lamaliseche, pali mwayi woti timitsempha timere tsitsi (5).Kuonjezera apo, ngati tsitsi la tsitsi labwino ndilofanana ndi la tsitsi lolimba, pali maselo okwanira mu epidermis ndi bulge (6), n'zotheka kupangitsa tsitsi kukhala lochepa komanso lochuluka mu dazi lachimuna.
Nthawi yotumiza: Dec-20-2022